A retinoic acid ester used in appearance-focused cosmetic products.
Sources: 1, 2, 3HPR
Avoid during pregnancy
Avoid during pregnancy as a topical-retinoid class precaution. This is not based on an HPR-specific pregnancy trial; obtain individualized breastfeeding advice.
Sources: 2Limited evidence
Hydroxypinacolone Retinoate
What it does
Studied combination products suggest potential cosmetic benefits, but do not establish the isolated contribution of this retinoid.
Sources: 1, 2, 3Good for
- Photoaging-focused formulas
How to use it
Follow the particular product's directions and tolerance advice. Do not combine multiple retinoids or copy prescription dosing without guidance.
Sources: 1, 2, 3Who should be careful
Can irritate. Avoid topical retinoids during pregnancy as a class precaution; breastfeeding use needs individualized advice.
Sources: 1, 2, 3Pairs well with
No supported pairings have been documented for this record.
Usage, safety and formulation details
Mechanism of action
Retinoid-related signaling has been proposed. Robust independent data on the isolated ingredient remain a review priority.
Sources: 1, 2, 3Potential adverse effects
Irritation, dryness and peeling can occur; evidence from a combination formula cannot establish the isolated ingredient's tolerance.
Sources: 1, 2, 3Formulation considerations
Differentiate the active percentage from the percentage of a supplier blend. Stability and delivery matter.
Sources: 1, 2, 3Pregnancy and breastfeeding
Avoid during pregnancy
Avoid during pregnancy as a topical-retinoid class precaution. This is not based on an HPR-specific pregnancy trial; obtain individualized breastfeeding advice.
Sources: 2Safety tags
- Fragrance allergen
- Not assessed
Not separately assessed in this draft.
- Essential oil
- Not assessed
Not separately assessed in this draft.
- Drying alcohol
- Not assessed
Not separately assessed in this draft.
What remains uncertain
- Exact concentration, final pH and the full composition of any unprovided finished product
Clinical evidence and research (1 studies)
Clinical evidence
Evidence for its main benefitLimited evidence
A cited study is entered below. Its formulation, exposure and limitations must be considered before applying the results to another product.
Sources: 1, 2, 3Hydroxypinacolone retinoate/peptide product versus fractional CO2 laser
- Design
- Clinical comparison of an HPR/peptide product with a procedure
- Population
- Not extracted into this record
- Studied concentration
- Not extracted into this record
- Duration
- Not extracted into this record
The combination product was evaluated for facial-aging outcomes.
Limitations: Multiple active components prevent attributing the result to isolated HPR. It is not pregnancy-safety evidence.
Small clinical studySources: 1Regulation and ingredient label names
Regulatory information
No jurisdiction-specific assessment is recorded. An inventory listing is not blanket approval.
Names on ingredient lists
hydroxypinacolone retinoate
Chemical identity and molecular structure
Chemical information
Chemical structure
No single structure to show yet
A reviewed, unambiguous PubChem compound identifier is needed before a molecular diagram can be displayed.
| Detail | Value | Source |
|---|---|---|
| material scope | One documented trade grade (Granactive Retinoid) contains 10% active in dimethyl isosorbide, so 2% of that blend would supply about 0.2% HPR. This does not establish any other product's concentration. | Hydroxypinacolone retinoate/peptide product versus fractional CO2 laser |
Content updated 9 November 2026.
Sources (3)
Scientific sources
- Hydroxypinacolone retinoate/peptide product versus fractional CO2 lasercombination-product study · 2024
- AAD: Pregnancy skincare and ingredients to avoidclinical guidance
- Grant Industries: Granactive Retinoid technical document (10% hydroxypinacolone retinoate in dimethyl isosorbide)manufacturer technical information
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