A nucleoside used in skincare products targeting the appearance of fine lines.
Sources: 1, 2Adenine riboside
Not assessed
No pregnancy- or breastfeeding-specific assessment has been completed for this record. A cosmetic safety review is not a pregnancy rating.
Limited evidence
Adenosine
What it does
Some adenosine-containing preparations have been studied for localized wrinkle appearance; results are specific to the delivery system.
Sources: 1, 2Good for
- Fine-line appearance
How to use it
Follow the finished product's directions and assess tolerance when introducing it. Ingredient research does not supply one universal dose or schedule.
Sources: 1, 2Who should be careful
Sensitive skin can react to the finished formula. This topical cosmetic record does not describe intravenous adenosine medicine.
Sources: 1, 2Pairs well with
No supported pairings have been documented for this record.
Usage, safety and formulation details
Mechanism of action
Adenosine acts through cell-surface receptors. Laboratory signaling findings do not establish the performance of every serum.
Sources: 1, 2Potential adverse effects
Irritation or contact allergy may occur; stop a product that causes a persistent or marked reaction.
Sources: 1, 2Formulation considerations
Solubility and delivery affect availability. Do not treat evidence for a dissolving film as evidence for an ordinary cream.
Sources: 1, 2Pregnancy and breastfeeding
Not assessed
No pregnancy- or breastfeeding-specific assessment has been completed for this record. A cosmetic safety review is not a pregnancy rating.
Safety tags
- Fragrance allergen
- Not assessed
Not separately assessed in this draft.
- Essential oil
- Not assessed
Not separately assessed in this draft.
- Drying alcohol
- Not assessed
Not separately assessed in this draft.
- May irritate sensitive skin
- Not assessed
Not separately assessed in this draft.
What remains uncertain
- Exact concentration, final pH and the full composition of any unprovided finished product
Clinical evidence and research (1 studies)
Clinical evidence
Evidence for its main benefitLimited evidence
A cited study is entered below. Its formulation, exposure and limitations must be considered before applying the results to another product.
Sources: 1, 2Adenosine-containing film: formulation and localized wrinkle study
- Design
- Randomized, placebo-controlled, investigator-blind study of a dissolving film
- Population
- Female volunteers
- Studied concentration
- 1% adenosine in the tested film
- Duration
- Not extracted into this record
The study reported localized wrinkle-related improvements with the delivery system.
Limitations: A film's delivery and exposure are different from those of an ordinary cream; do not extrapolate dosing.
Small clinical studySources: 2Regulation and ingredient label names
Regulatory information
No jurisdiction-specific assessment is recorded. An inventory listing is not blanket approval.
Names on ingredient lists
adenosine
Chemical identity and molecular structure
Chemical information
Chemical structure
| Detail | Value | Source |
|---|---|---|
| PubChem CID | 60961 | PubChem compound 60961: chemical identity |
| molecular formula | C10H13N5O4 | PubChem compound 60961: chemical identity |
| molecular weight | 267.24 g/mol | PubChem compound 60961: chemical identity |
Content updated 9 November 2026.
Sources (3)
Scientific sources
- CIR: Safety assessment of adenosinesafety assessment
- Adenosine-containing film: formulation and localized wrinkle studyhuman study
- PubChem compound 60961: chemical identitychemical identity
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